Experimental Pyelonephritis

Pyelonephritis. I. Observations on the Course of Chronic Non-Obstructed Enterococcal Infection in the Kidney of the Rat ‡

Studies of the pathogenesis of experimental pyelonephritis have been limited because of lack of a suitable model. Although several types of renal and extra-renal manipulations have been shown to predispose the kidneys of experimental animals to pyelonephritis, the investigator is frequently unable to distinguish between the effects of the predisposing injury and the induced infection. The few m...

Increased Susceptibility of Mice Infected with Mouse Adenovirus to Escherichia Coli-induced Pyelonephritis

Mouse adenovirus causes a persistent infection in the mouse kidney that produces extensive mononuclear cell infiltrates in cortex and medulla. Tubular necrosis, dilatation, and occasional collapse occur but no glomerular changes or periglomerular fibrosis have been observed. Acute and chronic adenovirus infection of the kidney predispose the kidney to develop acute pyelonephritis when the mouse...

A rare case of xanthogranulomatous pyelonepheritis with hepatic angiomyolipoma.

Xantogranulomatous pyelonephritis (XGP) is a rare and chronic variant of pyelonephritis typically associated with obstruction and infection. Xantogranulomatous pyelonephritis can infiltrate liver and connect with hepatic dysfunction. Here we report on a 52-year-old female with a liver mass and a left renal mass detected by uitrasonography and magnetic resonance imaging. Right lobectomy and part...

Endotoxin Tolerance. I. Its Induction by Experimental Pyelonephritis.

The Role of Immunity in the Pathogenesis of Experimental Retrograde Pyelonephritis

Retrograde pyelonephritis was produced in rats by the intravesical injection of Proteus mirabilis. When animals were preimmunized against Proteus mirabilis by (a) prior infection, (b) administration of antigen, or (c) passively transferred antiserum, they were resistant to infection by proteus when challenged by the retrograde route. The protective effect of specific preimmunization in retrogra...

Retrograde Proteus Pyelonephritis in Rats

Rats with retrograde proteus pyelonephritis were treated with antibiotics until their kidneys became sterile. Using fluorescent antibody techniques, specific P. mirabilis antigen was found in some sterile pyelonephritic kidneys 20 weeks after cessation of treatment and presumed renal sterilization. Persistent antigen was associated with interstitial chronic inflammation but not with acute infla...